Free Download Introduction to Clinical Biochemistry - Interpreting Blood Results PDF
This book is a concise introduction to the common blood tests and concepts used in pathology. It is aimed for undergraduate students reading medicine, nursing and midwifery and subjects allied to health such as Biomedical Science. However, since the book uses “example boxes” to explain complex terms in lay language, it should also be accessible to patients and people with a non-clinical background but an interest in the subject. The book is written in an informal style and allows for signposted learning of a complex subject through the use of further reading boxes, making it a suitable revision guide.
About Author
Dr Graham Basten is Associate Head of the School
of Allied Health Sciences at De Montfort University (UK). He holds a PhD
from the UK government’s Institute of Food Research and has researched
and lectured extensively over the past 10 years on clinical
biochemistry, nutrition and folate at the Universities of Sheffield and
Nottingham (UK). He is a De Montfort University Teacher Fellow and has
been nominated for the Vice Chancellor’s Distinguished Teaching Award.
As a senior lecturer in Clinical Chemistry, and as leader of the
undergraduate Projects module, this expertise and experience is
transferred to the concise introductory textbooks written for Book Boon.
Select research publications
1. Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Duthie SJ, Horgan G, de Roos B, Rucklidge G, Reid M, Duncan G, Pirie L, Basten GP, Powers HJ. J Proteome Res. 2010 Apr 5;9(4):1941-50
2. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH, Powers HJ. Br J Cancer. 2006 Jun 19;94(12):1942-7. Epub 2006 May 30
3. Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Narayanan S, McConnell J, Little J, Sharp L, Piyathilake CJ, Powers H, Basten G, Duthie SJ. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1436-43
4. Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes. Basten GP, Hill MH, Duthie SJ, Powers HJ. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1244-9
Content
1. Laboratory tests: Interpreting Results
1.1 A typical blood sciences service
1.2 Variables that may affect a result: Analytical
1.2.1 Analytical sensitivity and specificity
1.3 Standards
1.4 Quality Control: Within batch, between batch, external
1.4.1 Within batch variation
1.4.1 Between batch variation
1.4.1 External quality control
1.5 Control Plots
1.6 Precision, Accuracy, Bias
1.7 Variables that will affect a result: Physiological
1.7.1 Blood collection and storage techniques
1.7.2 The difference between plasma and serum
1.7.3 A haemolysed sample
1.7.4 Reference ranges
1.7.6 Clinical sensitivity and specificity
1.8 Summary
2. Overview of tests
2.1 Summary
3. The blood cells and liquid component: Full Blood Count (FBCs)
3.1 Red Blood Cell Indices
3.1.1 Red Blood Cell Number
3.1.2 Haemoglobin
3.1.3 Mean Cell Volume
3.1.4 Haematocrit (HCT)
3.2 White Blood Cell Indices
3.2.1 White Blood Cell Number
3.2.2 White Cell Differential
3.2.3 Neutrophils
3.2.4 Lymphocytes
3.2.5 Basophils and Eosinophils
3.2.7 Blast Atypical cells
3.3 Clotting Indices
3.3.1 Platelet Number
3.3.2 Prothrombin Time
3.3.3 Partial thromboplastin time
3.3.4 International Normalised Ratio
3.3.5 D-Dimers
3.4 Summary
4. Autoimmune and inflammation
4.1 Inflammation and CRP
4.2 Plasma Viscosity
4.3 Erythrocyte Sedimentation Rate
4.4 The inflammation trilogy
5. Liver function test (LFTs) and Enzymes
5.1 Enzymes
5.1.1 Measuring an enzyme
5.1.2 Activation energy
5.1.3 Factors which affect enzyme rate
5.1.4 Factors which inhibit enzymes
5.1.5 Extracellular vs. Intracellular
5.1.5 Isoenzymes
5.2 Bilirubin
5.3 Liver Enzymes
5.3.1 Aspartate aminotransferase (AST)
5.3.2 Alanine Aminotransferase (ALT)
5.3.3 Gamma-glutamyl transferase (GGT)
5.3.4 Alkaline phosphatase (ALP)
5.4 Summary
6. Kidney function tests and electrolytes (U&Es)
6.1 Electrolytes
6.1.1 Sodium (Na)
6.1.2 Potassium (K)
6.2 Urea and Creatinine
6.3 Glomerular filtration rate (GFR)
6.4 Uric acid and gout
6.5 Summary
7. The bone and calcium (bone profile)
7.1 Corrected calcium
7.2 Calcium control
7.3 Bone diseases
7.3.1 Osteoporosis
7.3.2 Paget’s disease
7.3.3 Osteomalacia and rickets
7.3.4 Differentiating between bone diseases
Site
Free Download e book
Free Download Introduction to Clinical Biochemistry - Interpreting Blood Results PDF
Select research publications
1. Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Duthie SJ, Horgan G, de Roos B, Rucklidge G, Reid M, Duncan G, Pirie L, Basten GP, Powers HJ. J Proteome Res. 2010 Apr 5;9(4):1941-50
2. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH, Powers HJ. Br J Cancer. 2006 Jun 19;94(12):1942-7. Epub 2006 May 30
3. Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Narayanan S, McConnell J, Little J, Sharp L, Piyathilake CJ, Powers H, Basten G, Duthie SJ. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1436-43
4. Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes. Basten GP, Hill MH, Duthie SJ, Powers HJ. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1244-9
Content
1. Laboratory tests: Interpreting Results
1.1 A typical blood sciences service
1.2 Variables that may affect a result: Analytical
1.2.1 Analytical sensitivity and specificity
1.3 Standards
1.4 Quality Control: Within batch, between batch, external
1.4.1 Within batch variation
1.4.1 Between batch variation
1.4.1 External quality control
1.5 Control Plots
1.6 Precision, Accuracy, Bias
1.7 Variables that will affect a result: Physiological
1.7.1 Blood collection and storage techniques
1.7.2 The difference between plasma and serum
1.7.3 A haemolysed sample
1.7.4 Reference ranges
1.7.6 Clinical sensitivity and specificity
1.8 Summary
2. Overview of tests
2.1 Summary
3. The blood cells and liquid component: Full Blood Count (FBCs)
3.1 Red Blood Cell Indices
3.1.1 Red Blood Cell Number
3.1.2 Haemoglobin
3.1.3 Mean Cell Volume
3.1.4 Haematocrit (HCT)
3.2 White Blood Cell Indices
3.2.1 White Blood Cell Number
3.2.2 White Cell Differential
3.2.3 Neutrophils
3.2.4 Lymphocytes
3.2.5 Basophils and Eosinophils
3.2.7 Blast Atypical cells
3.3 Clotting Indices
3.3.1 Platelet Number
3.3.2 Prothrombin Time
3.3.3 Partial thromboplastin time
3.3.4 International Normalised Ratio
3.3.5 D-Dimers
3.4 Summary
4. Autoimmune and inflammation
4.1 Inflammation and CRP
4.2 Plasma Viscosity
4.3 Erythrocyte Sedimentation Rate
4.4 The inflammation trilogy
5. Liver function test (LFTs) and Enzymes
5.1 Enzymes
5.1.1 Measuring an enzyme
5.1.2 Activation energy
5.1.3 Factors which affect enzyme rate
5.1.4 Factors which inhibit enzymes
5.1.5 Extracellular vs. Intracellular
5.1.5 Isoenzymes
5.2 Bilirubin
5.3 Liver Enzymes
5.3.1 Aspartate aminotransferase (AST)
5.3.2 Alanine Aminotransferase (ALT)
5.3.3 Gamma-glutamyl transferase (GGT)
5.3.4 Alkaline phosphatase (ALP)
5.4 Summary
6. Kidney function tests and electrolytes (U&Es)
6.1 Electrolytes
6.1.1 Sodium (Na)
6.1.2 Potassium (K)
6.2 Urea and Creatinine
6.3 Glomerular filtration rate (GFR)
6.4 Uric acid and gout
6.5 Summary
7. The bone and calcium (bone profile)
7.1 Corrected calcium
7.2 Calcium control
7.3 Bone diseases
7.3.1 Osteoporosis
7.3.2 Paget’s disease
7.3.3 Osteomalacia and rickets
7.3.4 Differentiating between bone diseases
Site
Free Download e book
Free Download Introduction to Clinical Biochemistry - Interpreting Blood Results PDF
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