0 Free Download Pharmacokinetics e book PDF

 

Free Download Pharmacokinetics e book PDF
All the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered. The essential mathematical basis of PKs is explained, but excessive mathematical complexity is avoided. For all key equations, practical examples of their use are provided. There are plenty of practice questions (along with model answers). Additional spreadsheets are provided on the net.

Author

Dr Phil Rowe has spent over 30 years teaching quantitative topics relevant to the pharmaceutical sciences – including pharmacokinetics, pharmaceutical/clinical statistics and epidemiology. His speciality is explaining mathematically based topics to the non-mathematically minded, in both a university and a commercial setting.
www.phrData.co.uk

Content

Introduction

ADME and Pharmacokinetics

1. ADME – Absorption Distribution, Metabolism and Excretion
2. Pharmacokinetics

Absorption: Absorption rate constant, Bioavailability and Salt factor

1. Passive diffusion and other mechanisms by which drugs may cross biological membranes
2. Rate of drug absorption and the Absorption rate constant (Ka)
4. Bioavailability
5. Salt factor

Distribution: Compartments and Volume of Distribution

1. The rate of distribution and compartments
2. One compartment model
3. Two compartment model
4. The extent of distribution
5. Volume of distribution
6. Using the volume of distribution to calculate dose size
7. Practice calculations

Elimination: Elimination rate constant, half-life and clearance

1. Elimination rate constant and half-life
2. Clearance
3. Practice calculations

Single intravenous bolus injection into one compartment

1. Concentration versus time graph
2. Relationship between time and concentration
3. Area Under the Curve (AUC)
4. Practice calculations
5. Appendix 1
6. Appendix 2

Analysis of experimental data from a bolus i.v

injection into one compartment

1. Analysis of clinical trials data
2. Analysis of data arising in a clinical setting
3. Practice calculations
4. Appendix 1
5. Appendix 2

Single intravenous bolus injection into two compartments

1. The model to be considered
2. Drug concentrations in blood and the rest of the first compartment
3. Determining how many compartments a drug occupies
4. Drug concentration in the second compartment
5. Two compartment systems and therapeutic drug monitoring for digoxin

Constant intravenous infusion

1. The model to be considered
2. Concentration versus time curve during infusion
3. Relationship between rate of infusion and concentration at steady state
4. Loading doses
5. The accumulation period
6. Practice questions
7. Appendix

Extravascular administration

1. The situation to be considered
2. Concentration versus time curve
3. Changing the rate of absorption
4. Cmax and Tmax
5. Determination of bioavailability for extravascular doses
7. Trapezoidal rule – A practical method to measure AUC
8. Practice question
9. Appendix

Multiple dosing

1. Pharmacokinetic accumulation and steady state
2. Multiple extravascular doses
3. Concentrations at steady state
4. Loading dose
5. Accumulation stage
6. Extent of fluctuation in drug concentrations
7. Practice questions
8. Appendix

Non-linear pharmacokinetics

1. Considering drug metabolism as an enzyme catalysed reaction
2. Exceptions to linearity
3. Effect of non-linearity on the relationship between dose and drug concentration
5. Clinical significance of non-linear kinetics
6. Non-linear kinetics and drug development

Non-compartmental pharmacokinetics

1. The case for non-compartmental methods
2. Calculation methods
3. More complex situations

Computerized analysis of pharmacokinetic data

1. Least squares fitting
2. Practice question

Creatinine clearance

1. Clearance of creatinine and various drugs
2. Digoxin dosing
3. Practice questions

Pharmacokinetic symbols and equations

1. Symbols
2. Cockcroft and Gault equations

Additional material available from the internet

Answers to practice questions 

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Free Download Pharmacokinetics e book PDF

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