26 November 2012

0 Travel to Johannesburg & Pretoria ebook Free Download


Travel Guides
Travel to Johannesburg & Pretoria
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When you are traveling in South Africa than Johannesburg and Pretoria are two cities you can’t miss. Johannesburg is the largest city of South Africa and is divided in two areas, the old city and modern Sandton. Enjoy shopping or visit one of the many tourist attractions. Pretoria is a quieter city with many interesting museums. In this travel guide you find a historical outline, suggestions for daytrips and maps.


0 Travel to Cape Town ebook Free Download


Travel Guides
Travel to Cape Town
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Travel to Cape Town in South Africa, explorer Table Mountain and bring a visit to South Africa’s oldest building; the fort Castle of good hope. In this travel guide you find three inspiring tours which will guide you along the highlights of this modern South African city. This guide as well contains an historical outline, tour suggestions outside of Cape Town and maps.


0 Travel to Cairo ebook Free Download


Travel Guides
Travel to Cairo
Free Download ebook

Discover Egypt’s capital Cairo with this travel guide. Visit the pyramids and the Sphinx of Giza, Tutankhamen, The Egyptian Museum and the Alabaster Mosque. These are only a few of the many adventures which await a visitor of this city. In this travel guide you find an historical outline, suggestions for daytrips and a metro map.



0 Travel to Africa ebook Free Download



Travel Guides
Travel to Africa
Free Download ebook
Explore Egypt and South Africa. This continent has it all, beautiful nature, sunny beaches and historical sites. In this travel guide you find inspiring day trips, information about the most famous tourist attractions, comprehensive maps and an historical outline.


16 November 2012

0 Free Download Large Scale Data Handling in Biology e-book PDF



Free Download Large Scale Data Handling in Biology e-book PDF
Data Handling in Biology--the application of computational and analytical methods to biological problems--is a rapidly evolving scientific discipline. Written in a clear, engaging style, Large Scale Data Handling in Biology is for scientists and students who are learning computational approaches to biology. The book covers the data storage system, computational approaches to biological problems, an introduction to workflow systems, data mining, data visualization, and tips for tailoring existing data analysis software to individual research needs.

Content
1. What to Do with All the Data?
2. Data Storage, Backup and Archiving Architecture
2.1 Organization of HCS Informatics Infrastructure
2.2 Hardware and Network Infrastructure
2.3 Do we need robust Data Movers (DM) in High Content Screening for data-flow automation
3. Workflow Systems
3.1 Why is a workflow system important
3.2 Visualization in workflow systems
3.3 Architecture of workflow systems
3.4 Public Domain Workflow Systems
3.5 Commercial Workflow Systems
3.6 Summary and Vision
4. Database Development: Laboratory Information Management Systems and Public Databases
4.1 What Type of HCS Data Have to Be Managed in the Database
4.2 Database Schema
4.3 LIMS Architecture
4.4 LIMS and User Management System
4.5 Type of Users
4.6 Integration and Public Databases
References

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13 November 2012

0 Kinetics for Bioscientist e-book PDF Free Download






Free Download Kinetics for Bioscientist e-book PDF
This book starts off by discussing the basics of kinetics, using everyday examples. It then moves on to describing kinetics in mathematical terms. Special chapters in this book are dedicated to cases relevant for Bioscientists, e.g. zero, first and second order kinetics. In the last part of the book, the focus is on more complex applications of kinetics, e.g. steady-state reactions and the kinetics of equilibria. An important aspect is to provide relevant examples and model calculations. Every theoretical approach is underpinned by several model calculations of real-life examples.

Content

1. Why a Bioscientist should care about kinetics
1.1 Introduction and learning outcomes
1.2 Problem: Elimination of alcohol from the body
1.3 Problem: Growth of an E.coli culture
1.4 Problem: Cancer
1.5 Summary
2. Rates, speeds and velocities
2.1 Introduction and learning outcomes
2.2 Definitions
2.3 Average and instantaneous rates
2.4 Working with instantaneous rates
2.5 Summary
3. Zero Order Reactions
3.1 Introduction and learning outcomes
3.2 Some definitions for zero order reactions
3.3 Developing the tools for a zero order reaction
3.4 Problem: Elimination of a drug from the metabolism
3.5 Problem: Transport of growth hormone receptor to cell membrane
3.6 Which equation should I use to calculate the product of a reaction?
3.7 Problem solving strategies
3.8 Equations for zero order reactions
3.9 More practice questions
4. First order reaction
4.1 Introduction and learning outcomes
4.2 Some definitions for first order reactions
4.3 Developing the tools for a first order reaction
4.4 Problem: Elimination of a drug from the metabolism
4.5 Problem: Radioactive decay
4.6 Problem: Degradation of a receptor/ligand dimer
4.7 Problem: Growth of a population
4.8 Problem Solving Strategies
4.9 Equations for a first order reaction
4.10 More practice questions
5. Second order reaction – a special case
5.1 Introduction and learning outcomes
5.2 Some general definitions of a second order reaction
5.3 Developing the tools for a second order reaction
5.4 Problem: Dimerization of the receptor for a growth hormone
5.5 Problem: Formation of active reverse transcriptase dimers
5.6 Problem solving strategies
5.7 Equations for second order reactions in which the reactants are the same chemical
5.8 More practice questions
6. Second order reaction with different reactants
6.1 Introduction and learning outcomes
6.2 Extension of the second order rate concept
6.3 Pseudo-orders
6.4 Problem: Hydrolysis of Acetylcholine
6.5 Problem solving strategies
7. Determine the order of a reaction
7.1 Introduction and learning outcomes
7.2 The significance of ‘initial rates’
7.3 Effect of reactant concentrations on rates
7.4 Equations for the determination of rate orders
7.5 Problem: Determine the rate order of a reaction
7.6 Rate orders and Molecularity of a reaction
7.7 Fractal and negative rate orders
7.8 Problem Solving Strategy
7.9 More practice questions
8. Complex reactions with several reactants
8.1 Introduction and learning outcomes
8.2 The general rate law expression for reactions with several reactants
8.3 Determining individual rate orders from experimental data
8.4 Determine the rate constant for a reactions with several reactants
8.5 Problem: Calculate rates and concentrations of reactants from data sets
8.6 Problem Solving Strategy
8.7 More practice questions
9. Coupled reactions
9.1 Introduction and learning outcomes
9.2 The General Mass Action (GMA) representation for complex reactions
9.3 The GMA representation for a reversible reaction
9.4 Problem: Calculate the equilibrium constant of a complex reversible reaction
9.5 Problem: Calculating equilibrium concentrations from rate constants
9.6 Problem solving strategies
9.7 More problem questions
10. Model Answers to practice questions
10.1 Answers to Chapter 3
10.2 Answers to Chapter 4
10.3 Answers to Chapter 5
10.4 Answers to Chapter 7
10.5 Answers to Chapter 8
10.6 Answers to Chapter 9

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0 Free Download Molecular Conformations e-book PDF






Free Download Molecular Conformations e-book PDF
The three-dimensional shape of a protein determines its function. The shape of proteins can change by small or large amounts; another term for shape is conformation.
Molecular Conformations introduces the fundamental physical and biochemical concepts that determine the conformation of a protein. The book starts by describing how DNA is converted into proteins and then continues with those factors that influence conformational change in a protein.
The book is essential reading for anyone who wants to understand how proteins execute their biochemical functions.

Content

1. Genetic origins of amino acids
1.1 Constituents and organisation of DNA
1.2 Folding of DNA
1.3 The codon structure of DNA
1.4 Gene structure
2. Transcription and translation
2.1 Transcription
2.2 Translation
2.2.1 Transfer RNA
2.2.2 Protein formation by ribosomes
2.2.3 Open reading frames of mRNA
3. Amino acid geometries and protein folding
3.1 Amino acid structure and bond flexibility
3.2 Principles of protein folding
3.2.1 Formation of secondary-structure elements
3.2.2 Causes and consequences of misfolding
3.2.3 Mechanisms of protein folding
4. Structure-function relationship of proteins
4.1 Relevance of pH and isoelectric point to proteins
4.2 Surface electrostatic potential
4.3 Affinity and specificity
4.4 Allosteric activation
5. Conformational change via epigenetics
5.1 DNA methylation
5.2 Definition of PTMs
5.3 Bromodomains
5.4 Chromodomains
5.5 Domains that bind phosphorylated serines
6. Summary

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0 Free Download Introduction to Scientific Research Projects e-book PDF





Free Download Introduction to Scientific Research Projects e-book PDF
Introduction to Scientific Research Projects is a concise introduction to the undergraduate scientific research project. It is primarily aimed at undergraduate students reading medicine, nursing and midwifery and subjects allied to health such as Biomedical Science who will be expected to undertake some kind of research project as part of their degree. Exploring the different types of projects, and individual components of dissemination (poster, oral, viva, and thesis), by using tips, example boxes, and analogies, it makes an easy and enjoyable read for both students and supervisors alike.
Author


Dr Graham Basten is Associate Head of the School of Allied Health Sciences at De Montfort University (UK). He holds a PhD from the UK government’s Institute of Food Research and has researched and lectured extensively over the past 10 years on clinical biochemistry, nutrition and folate at the Universities of Sheffield and Nottingham (UK). He is a De Montfort University Teacher Fellow and has been nominated for the Vice Chancellor’s Distinguished Teaching Award. As a senior lecturer in Clinical Chemistry, and as leader of the undergraduate Projects module, this expertise and experience is transferred to the concise introductory textbooks written for Book Boon.
Select research publications
1. Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Duthie SJ, Horgan G, de Roos B, Rucklidge G, Reid M, Duncan G, Pirie L, Basten GP, Powers HJ. J Proteome Res. 2010 Apr 5;9(4):1941-50
2. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH, Powers HJ. Br J Cancer. 2006 Jun 19;94(12):1942-7. Epub 2006 May 30
3. Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Narayanan S, McConnell J, Little J, Sharp L, Piyathilake CJ, Powers H, Basten G, Duthie SJ. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1436-43
4. Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes. Basten GP, Hill MH, Duthie SJ, Powers HJ. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1244-9

Content

Introduction to Scientific Research Projects
1. What is an undergraduate scientific research project?
1.1 How is it different to other types of assessment?
1.2 How is different to other types of research projects?
1.3 What types of research projects are there?
1.4 What project will best fit my personality?
1.5 What will I be expected to do and learn?
1.5.1 Critiques
1.5.2 Research grant
1.5.3 Literature review
1.5.4 Oral presentations
1.5.5 Poster session
1.5.6 Notebook, diary or blog (online diary)
1.5.7 Thesis
1.5.8 Oral viva
1.6 Summary
2. Choosing your project, hopes and expectations
2.1 When to chose your project
2.2 Hopes
2.3 Expectations
2.3.1 Refining your project
2.4 Summary
3. Planning your project
3.1 Time management
3.2 Student supervisor responsibility
3.3 Research personnel
3.4 Etiquette and survival tips
3.4.1 Supervisor meetings (journal clubs)
3.4.2 Notebook or blog
3.4.3 Hours and requesting equipment
3.5 Staying alive and not being sent to prison (safety and ethics)
3.7 Plagiarism and academic offences
3.8 Summary
4. Critiquing existing research
4.1 Choosing a paper to review
4.2 Writing the critique
4.3 Critiquing a research grant
5. Experimental design
5.1 Planning the experiment
5.2 Controls
5.3 Performance, feedback, revision
5.4 Summary
6. The scientific poster presentation
7. The scientific oral presentation
7.1 Constructing the presentation
7.2 Navigating the session
7.3 Viva Voce
7.4 Summary
8. The thesis and scientifi c writing
8.1 Preparation
8.2 The thesis sections in more detail
8.2.1 Title
8.2.2 Dedication
8.2.3 Acknowledgements
8.2.4 Authorship
8.2.5 Abstract
8.2.6 Contents
8.2.7 Introduction
8.2.8 Materials and methods
8.2.9 Results
8.2.10 Conclusion
8.2.11 References
8.2.12 Appendices
8.2.13 Assessment Scheme
8.3 Summary
9. Summary
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0 Free Download A Wet Look At Climate Change - Hurricanes to House Mites e-book PDF





Free Download A Wet Look At Climate Change - Hurricanes to House Mites e-book PDF
The term “Climate Change” has become popular but is not new to our planet. Our climate changes, sometimes dramatically, sometimes gradually, but it always changes. We hear about the wettest month on record, countrywide floods, record high and low temperatures, global warming...how do these changes in weather affect things around us? “A Wet Look at Climate Change” introduces the basics about moisture in air, which is the driving force for our weather. The subsequent chapters cover a range of everyday examples showing the impact these weather changes have around our home, garden and workplace.

Author
Dr Peter Moir is an independent pharmaceutical consultant at working in Ireland. Peter is also a director of Relequa Analytical Systems Limited, a company set up to specifically provide an analytical tool for looking at moisture interactions in materials. Peter has worked in research and product development within the biotechnology and pharmaceutical industries. He has a degree in applied chemistry and received a doctorate degree in molecular biology. Also, last year he was awarded a postgraduate diploma in enterprise development. Peter has presented at international conferences and published articles in the area of moisture interactions in materials in the pharmaceutical industry.
Content


  • Acknowledgments
  • Introduction
  • Relative Humidity
  • Saturation
  • Equilibrium Relative Humidity
  • Hurricanes, Typhoons and Cyclones
  • Health
  • Food
  • Potato Blight
  • Salt
  • ERH Revisited
  • How Much Water?
  • Oh Poor Olive Tree!
  • Oil + Water = ?
  • House Mites
  • A Challenge 
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    0 Free Download Micro- and Nano-Transport of Biomolecules e-book PDF





    Free Download  Micro- and Nano-Transport of Biomolecules e-book PDF
    This e-book introduces the reader to biomolecules and describes the experimental and theoretical aspects of their micro- and nano-scale motion in water. Particular emphasis is given to their transport in engineered micro-environments where they are driven by externally imposed electric fields. Envisaged application technologies of this wide-ranging science involve healthcare, food provisioning, environmental services, etc. The e-book is generally intended for undergraduate students studying chemical, life, physical and engineering sciences, and also interdisciplinary researchers.

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    0 Free Download Pharmacokinetics e book PDF







    Free Download Pharmacokinetics e book PDF
    All the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered. The essential mathematical basis of PKs is explained, but excessive mathematical complexity is avoided. For all key equations, practical examples of their use are provided. There are plenty of practice questions (along with model answers). Additional spreadsheets are provided on the net.

    Author
    Dr Phil Rowe has spent over 30 years teaching quantitative topics relevant to the pharmaceutical sciences – including pharmacokinetics, pharmaceutical/clinical statistics and epidemiology. His speciality is explaining mathematically based topics to the non-mathematically minded, in both a university and a commercial setting.
    www.phrData.co.uk

    Content

  • Introduction
  • ADME and Pharmacokinetics
    1. ADME – Absorption Distribution, Metabolism and Excretion
    2. Pharmacokinetics
  • Absorption: Absorption rate constant, Bioavailability and Salt factor
    1. Passive diffusion and other mechanisms by which drugs may cross biological membranes
    2. Rate of drug absorption and the Absorption rate constant (Ka)
    3. Bioavailability
    4. Salt factor
  • Distribution: Compartments and Volume of Distribution
    1. The rate of distribution and compartments
    2. One compartment model
    3. Two compartment model
    4. The extent of distribution
    5. Volume of distribution
    6. Using the volume of distribution to calculate dose size
    7. Practice calculations
  • Elimination: Elimination rate constant, half-life and clearance
    1. Elimination rate constant and half-life
    2. Clearance
    3. Practice calculations
  • Single intravenous bolus injection into one compartment
    1. Concentration versus time graph
    2. Relationship between time and concentration
    3. Area Under the Curve (AUC)
    4. Practice calculations
    5. Appendix 1
    6. Appendix 2
  • Analysis of experimental data from a bolus i.v
  • injection into one compartment
    1. Analysis of clinical trials data
    2. Analysis of data arising in a clinical setting
    3. Practice calculations
    4. Appendix 1
    5. Appendix 2
  • Single intravenous bolus injection into two compartments
    1. The model to be considered
    2. Drug concentrations in blood and the rest of the first compartment
    3. Determining how many compartments a drug occupies
    4. Drug concentration in the second compartment
    5. Two compartment systems and therapeutic drug monitoring for digoxin
  • Constant intravenous infusion
    1. The model to be considered
    2. Concentration versus time curve during infusion
    3. Relationship between rate of infusion and concentration at steady state
    4. Loading doses
    5. The accumulation period
    6. Practice questions
    7. Appendix
  • Extravascular administration
    1. The situation to be considered
    2. Concentration versus time curve
    3. Changing the rate of absorption
    4. Cmax and Tmax
    5. Determination of bioavailability for extravascular doses
    6. Trapezoidal rule – A practical method to measure AUC
    7. Practice question
    8. Appendix
  • Multiple dosing
    1. Pharmacokinetic accumulation and steady state
    2. Multiple extravascular doses
    3. Concentrations at steady state
    4. Loading dose
    5. Accumulation stage
    6. Extent of fluctuation in drug concentrations
    7. Practice questions
    8. Appendix
  • Non-linear pharmacokinetics
    1. Considering drug metabolism as an enzyme catalysed reaction
    2. Exceptions to linearity
    3. Effect of non-linearity on the relationship between dose and drug concentration
    4. Clinical significance of non-linear kinetics
    5. Non-linear kinetics and drug development
  • Non-compartmental pharmacokinetics
    1. The case for non-compartmental methods
    2. Calculation methods
    3. More complex situations
  • Computerized analysis of pharmacokinetic data
    1. Least squares fitting
    2. Practice question
  • Creatinine clearance
    1. Clearance of creatinine and various drugs
    2. Digoxin dosing
    3. Practice questions
  • Pharmacokinetic symbols and equations
    1. Symbols
    2. Cockcroft and Gault equations
  • Additional material available from the internet
  • Answers to practice questions 
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  • 0 Free Download Introduction to Cancer Biology e book PDF



    Free Download Introduction to Cancer Biology e book PDF

    Introduction to Cancer Biology is a short primer on how cancers develop and grow. The aim of this book is to provide a gentle exploration of the fundamental concepts in a easy-to-understand format, using examples and key figures for illustration. It is written in a style to help the reader understand the six basic principles that inform our current understanding of cancer, at the molecular, cellular and physiological level. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology.

    About Author

    Dr. Momna V Hejmadi

    Senior Fellow
    Dept. Biology & Biochemistry
    University of Bath
    BATH BA2 7AY
    United Kingdom
    Web: http://www.bath.ac.uk/bio-sci/research/profiles/hejmadi-m.html
    Tel: ++44(0)1225 383129
    Fax: ++44(0)1225 386779
    Email: bssmvh@bath.ac.uk

    Short Biography

    Dr. Hejmadi completed her PhD in radiation oncology, studying the biochemical basis of thermotolerance in murine tumours in vivo. Her postdoctoral research on the anti-tumour effects of novel bioreductive drugs in radio and chemotherapy in murine tumours, has led to the drug currently undergoing Phase II clinical trials. Currently, her research interests are in hypoxia signalling pathways in neuronal and cancer models in vitro. She has been teaching cancer biology to undergraduate students at Bath for the past 10 years and has won several awards for her teaching. She has created novel interactive Flash e-resources on this topic, which will soon be part of a UK HEA Open Educational Resources database.

    Select research publications

    1. Wirrig C, Wilbrey A, Tang TT and Hejmadi MV (2010) Nornicotine-based glycation attenuates β-amyloid aggregation and protects SHSY-5Y neuroblastoma cells (manuscript under preparation – to be submitted to J. Neurochemistry)
    2. W Wu, S Crennell, M Danson, D Hough, MV Hejmadi (2010) A novel photolyase from a haloarchaeon, Haloferax volcanii, enhances survival against uv-induced DNA damage (manuscript under preparation – to be submitted to J. Molecular Biology)
    3. M Batisson, N Strazielle, M Hejmadi, D Thomas,1 J F Ghersi-Egea, J Etienne, F Vandenesch, G Lina. (2006) Toxic shock syndrome toxin1 challenges neuroprotective functions of the choroidal epithelium and induces neurotoxicity. J. Infectious Diseases Aug 1;194(3):341-9.
    4. MV Hejmadi, F Dajas-Bailador, SM Barns, B Jones and S Wonnacott (2003) Neuroprotection by nicotine against hypoxia-induced apoptosis in cortical cultures involves activation of multiple nicotinic acetylcholine receptor subtypes Molecular and Cellular Neuroscience 24 (3):779-86.
    5. MV Hejmadi, NS Delany, S Jagannathan, GCColes & AJ Wolstenholme (2000) L-Glutamate binding sites of parasitic nematodes: an association with ivermectin resistance? Parasitology (120)535 – 545.
    6. OP Friery, MV Hejmadi and SR McKeown (1997) DNA damage induced in T50/80 tumour cells following exposure to the bioreductive drug tirapazamine in combination with a single dose of radiation (12Gy). Biochemical Society Transactions, 25, 135S (30% contribution)
    7. MV Hejmadi, SR McKeown, OP Friery, IA McIntyre, LH Patterson and DG Hirst (1996) DNA damage following combination of radiation with bioreductive drug AQ4N: possible selective toxicity to oxic & hypoxic tumour cells Br J Cancer, 73, 499-505
    8. SR McKeown, OP Friery, IA McIntyre, MV Hejmadi, LH Patterson and DG Hirst (1996) Evidence for therapeutic gain when AQ4N or tirapazamine is combined with radiation British J. Cancer, S39 - S42
    9. OP Friery, MV Hejmadi, IA McIntyre, JJA McAleer LH Patterson and SR McKeown (1996) Interaction of the novel drug AQ4N with radiation in BDF mice implanted with the T50/80 tumour Irish J.Med.Sci, 165,4: 310.
    10. SR McKeown, MV Hejmadi, IA McIntyre, JJ McAleer, LH Patterson (1995) AQ4N showing bioreductive potential & positive interaction with radiation in vivo. Br J Cancer. 1995 Jul;72(1):76-81. (50% contribution)
    11. Sharma M, Srinivasan VT, Singh BB (1993) Longitudinal (T1) and transverse (T2) relaxation times of tissue water protons in mouse developing sarcoma 180-A: effect of hyperthermia. Int J Hyperthermia. 1993 Nov-Dec;9 (6):811-9.

    Teaching publications

    1. M V Hejmadi (2007) Improving the effectiveness and efficiency of teaching large classes: Development and evaluation of a novel e-resource in cancer biology. Bioscience Education Electronic Journal Vol 9-2 (http://www.bioscience.heacademy.ac.uk/journal/vol9/beej-9-2.htm)
    2. MV Hejmadi (2008) Mentoring scientific minds through group research projects http://www.heacademy.ac.uk/TeachingGuides
    3. K. Bullock, Gould G, Hejmadi MV, Lock G (2009) Work Placement Experience: Should I Stay or Should I Go? Higher Education Reseach Development 28 (5), pp. 481-494.
    4. Lock, G., Bullock, K., Gould, V., Hejmadi, M.V, (2009). Exploring the Industrial-Placement Experience for Mechanical Engineering Undergraduates. Engineering Education: Journal of the Higher Education Academy, Engineering Subject Centre (4) (1), pp. 42-51.
    5. M V Hejmadi (2009) How effective is peer assessment and feedback? An evaluation across diverse teaching activities (Science Learning Teaching Conference, June 16-17, 2009 http://www.bioscience.heacademy.ac.uk/ftp/events/sltc09/presentations/o16hejmadi.pdf )
    6. M V Hejmadi (2009) Laboratory practicals: Strategies to enhance student learning (Science Learning Teaching Conference, June 16-17, 2009, http://www.bioscience.heacademy.ac.uk/ftp/events/sltc09/posters/p5hejmadi.pdf )
    7. M V Hejmadi (2010) Evaluating a Cancer Biology learning package for OER. OER10 Conference, March 22, 2010. http://www.ucel.ac.uk/oer10/programme_day1.html

    AWARDS

    - Mary Tasker Award for Excellence in Teaching 2002
    - Innovations in Learning and Teaching Award 2008
    - Finalists UK HEA Ed Wood Teaching Awards 2009
    - Nominated Times Higher Education ‘Innovations in Teaching’ award 2009
    Content
    1. How cancer arises
    1.1 Defining cancer
    1.2 Cancer is clonal in origin
    1.3 Insights into cancer
    1.4 Causes of cancer (aetiology of cancer)
    1.4.1 Lifestyle and Environment
    1.4.2 Age
    1.5 Identification and histopathology of cancers
    1.6 The 6 hallmarks of cancer
    2. Immortality: Continuous cell division
    3. Sustained growth signals (oncogenes)
    4. Bypass anti-growth signals (Tumour Suppressor Genes)
    5. Avoidance of cell death (apoptosis)
    5.1 When does apoptosis occur?
    5.2 What triggers apoptosis?
    5.3 How does apoptosis occur?
    6. Ensuring blood vessel growth (angiogenesis)
    7. Spread to other sites (metastasis)
    7.1 What are the stages of metastasis?
    7.2 Key molecules involved in metastasis
    8. Summary and some thoughts for the future

    Site

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    0 Free Download Introduction to Clinical Biochemistry - Interpreting Blood Results PDF


     Free Download Introduction to Clinical Biochemistry - Interpreting Blood Results PDF
    This book is a concise introduction to the common blood tests and concepts used in pathology. It is aimed for undergraduate students reading medicine, nursing and midwifery and subjects allied to health such as Biomedical Science. However, since the book uses “example boxes” to explain complex terms in lay language, it should also be accessible to patients and people with a non-clinical background but an interest in the subject. The book is written in an informal style and allows for signposted learning of a complex subject through the use of further reading boxes, making it a suitable revision guide.
    About Author 
    Dr Graham Basten is Associate Head of the School of Allied Health Sciences at De Montfort University (UK). He holds a PhD from the UK government’s Institute of Food Research and has researched and lectured extensively over the past 10 years on clinical biochemistry, nutrition and folate at the Universities of Sheffield and Nottingham (UK). He is a De Montfort University Teacher Fellow and has been nominated for the Vice Chancellor’s Distinguished Teaching Award. As a senior lecturer in Clinical Chemistry, and as leader of the undergraduate Projects module, this expertise and experience is transferred to the concise introductory textbooks written for Book Boon.
    Select research publications
    1. Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Duthie SJ, Horgan G, de Roos B, Rucklidge G, Reid M, Duncan G, Pirie L, Basten GP, Powers HJ. J Proteome Res. 2010 Apr 5;9(4):1941-50
    2. Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH, Powers HJ. Br J Cancer. 2006 Jun 19;94(12):1942-7. Epub 2006 May 30
    3. Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Narayanan S, McConnell J, Little J, Sharp L, Piyathilake CJ, Powers H, Basten G, Duthie SJ. Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1436-43
    4. Effect of folic Acid supplementation on the folate status of buccal mucosa and lymphocytes. Basten GP, Hill MH, Duthie SJ, Powers HJ. Cancer Epidemiol Biomarkers Prev. 2004 Jul;13(7):1244-9

    Content
    1. Laboratory tests: Interpreting Results
    1.1 A typical blood sciences service
    1.2 Variables that may affect a result: Analytical
    1.2.1 Analytical sensitivity and specificity
    1.3 Standards
    1.4 Quality Control: Within batch, between batch, external
    1.4.1 Within batch variation
    1.4.1 Between batch variation
    1.4.1 External quality control
    1.5 Control Plots
    1.6 Precision, Accuracy, Bias
    1.7 Variables that will affect a result: Physiological
    1.7.1 Blood collection and storage techniques
    1.7.2 The difference between plasma and serum
    1.7.3 A haemolysed sample
    1.7.4 Reference ranges
    1.7.6 Clinical sensitivity and specificity
    1.8 Summary
    2. Overview of tests
    2.1 Summary
    3. The blood cells and liquid component: Full Blood Count (FBCs)
    3.1 Red Blood Cell Indices
    3.1.1 Red Blood Cell Number
    3.1.2 Haemoglobin
    3.1.3 Mean Cell Volume
    3.1.4 Haematocrit (HCT)
    3.2 White Blood Cell Indices
    3.2.1 White Blood Cell Number
    3.2.2 White Cell Differential
    3.2.3 Neutrophils
    3.2.4 Lymphocytes
    3.2.5 Basophils and Eosinophils
    3.2.7 Blast Atypical cells
    3.3 Clotting Indices
    3.3.1 Platelet Number
    3.3.2 Prothrombin Time
    3.3.3 Partial thromboplastin time
    3.3.4 International Normalised Ratio
    3.3.5 D-Dimers
    3.4 Summary
    4. Autoimmune and inflammation
    4.1 Inflammation and CRP
    4.2 Plasma Viscosity
    4.3 Erythrocyte Sedimentation Rate
    4.4 The inflammation trilogy
    5. Liver function test (LFTs) and Enzymes
    5.1 Enzymes
    5.1.1 Measuring an enzyme
    5.1.2 Activation energy
    5.1.3 Factors which affect enzyme rate
    5.1.4 Factors which inhibit enzymes
    5.1.5 Extracellular vs. Intracellular
    5.1.5 Isoenzymes
    5.2 Bilirubin
    5.3 Liver Enzymes
    5.3.1 Aspartate aminotransferase (AST)
    5.3.2 Alanine Aminotransferase (ALT)
    5.3.3 Gamma-glutamyl transferase (GGT)
    5.3.4 Alkaline phosphatase (ALP)
    5.4 Summary
    6. Kidney function tests and electrolytes (U&Es)
    6.1 Electrolytes
    6.1.1 Sodium (Na)
    6.1.2 Potassium (K)
    6.2 Urea and Creatinine
    6.3 Glomerular filtration rate (GFR)
    6.4 Uric acid and gout
    6.5 Summary
    7. The bone and calcium (bone profile)
    7.1 Corrected calcium
    7.2 Calcium control
    7.3 Bone diseases
    7.3.1 Osteoporosis
    7.3.2 Paget’s disease
    7.3.3 Osteomalacia and rickets
    7.3.4 Differentiating between bone diseases

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    0 Free Download Biological Signal Analysis





    Free Download Biological Signal Analysis
    This textbook will provide the reader with an understanding of biological signals and digital signal analysis techniques such as conditioning, filtering, feature extraction, classification and statistical validation for solving practical biological signal analysis problems using MATLAB.
    About Author
    Dr Ramaswamy Palaniappan
    BE, MEngSc, PhD, SMIEEE, MIET, MBMES
    School of Computer Science and Electronic Engineering
    University of Essex, United Kingdom

    Content 
    1. Introduction
    1.1 A Typical Biological Signal Analysis Application
    1.2 Examples of Common Biological Signals
    1.2.1 Electrocardiogram
    1.2.2 Electroencephalogram
    1.2.3 Evoked Potential
    1.2.4 Electromyogram
    1.2.5 Phonocardiogram
    1.2.6 Other Biological Signals
    1.3 Contents of this book
    1.4 References
    2. Discrete-time signals and systems
    2.1 Discrete-time signal
    2.1.1 Sampling
    2.1.2 Aliasing
    2.2 Sequences
    2.3 Basic Discrete-time System Operations
    2.3.1 Product (modulation)
    2.3.2 Addittion
    2.3.3 Multiplication
    2.3.4 Time reversal (folding)
    2.3.5 Branching
    2.3.6 Time shifting
    2.3.7 Time scaling
    2.3.8 Combination of operations
    2.4 Examples on sequence operations
    2.5 Bibliography
    3. Fourier transform
    3.1 Discrete frequency
    3.2 Discrete Fourier transform
    3.3 DFT computation using matrix relation
    3.4 Picket fence effect
    3.5 Effects of truncation
    3.6 Examples of using DFT to compute magnitude spectrum
    3.7 Periodogram
    3.7.1 Welch method
    3.8 References
    4. Digital Filtering
    4.1 Filter Specifi cations
    4.1.1 Low-pass filter
    4.1.2 High-pass filter
    4.1.3 Band-pass and band-stop filters
    4.2 Direct fi ltering in frequency domain
    4.3 Time domain filtering
    4.4 Simple FIR filters
    4.4.1 Increasing the order of the simple filter
    4.4.2 BPF design using sum and difference filter
    4.5 FIR filter design using window method
    4.6 IIR Filter design
    4.7 References
    5. Feature extraction
    5.1 Simple features
    5.2 Correlation
    5.2.1 Choosing the autoregressive model order
    5.2.2 Autoregressive model to predict signal values
    5.2.3 Autoregressive coeffi cients as features to discriminate mental tasks
    5.3 Spectral features – Power spectral density
    5.4 Power spectral density derived features
    5.4.1 Asymmetry ratio PSD
    5.4.2 Spectral correlation/coherence
    5.4.3 Spectral peaks
    5.5 Power spectral density computation using AR features
    5.6 Hjorth descriptors
    5.7 Time domain features
    5.8 Joint time-frequency features
    5.9 References
    6. Classification methodologies
    6.1 What is classifi cation?
    6.2 Nearest Neighbour classifier
    6.2.1 k-NN algorithm
    6.2.2 Advantages and disadvantages of k-NN classifier
    6.2.3 MATLAB program for k-NN
    6.2.4 Reducing k-NN training dataset size
    6.2.5 Condensed Nearest Neighbour
    6.2.6 Edited Nearest Neighbour
    6.3 Artificial neuron
    6.4 Multilayer-Perceptron neural network
    6.5 MLP-BP classifi er architecture
    6.5.1 Training MLP-BP classifier
    6.5.2 Testing the performance of MLP-BP classifier
    6.5.3 MLP-BP classifi er implementation using MATLAB
    6.5.4 MLP-BP problems
    6.6 Performance measures
    6.7 Cross validation
    6.7.1 Equal class weight
    6.7.2 Leave one out
    6.8 Statistical measure to compare two methods
    6.8.1 Hypothesis testing
    6.9 References
    7. Applications
    7.1 Ectopic beat detection using ECG and BP signals
    7.2 EEG based brain-computer interface design
    7.2.1 BCI based on transient visual evoked potential
    7.2.2 BCI based on mental tasks
    7.3 Short-term visual memory impairment in alcohol abusers using visual evoked potential signals
    7.4 Identification of heart sounds using phonocardiogram
    7.5 References
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